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Long-term outcomes after an aggressive resection of adenosquamous carcinoma of the pancreas.
- Source :
-
Surgery Today . Oct2019, Vol. 49 Issue 10, p809-819. 11p. - Publication Year :
- 2019
-
Abstract
- Purpose: Adenosquamous carcinoma (ASC) of the pancreas is a rare malignancy, associated with a poor prognosis after surgical resection, with reported median survival times (MSTs) ranging from 4.4 to 13.1 months. We conducted this study to investigate the long-term outcomes of patients after the resection for ASC. Methods: Between 2002 and 2016, a total of 456 patients underwent resection for ASC or adenocarcinoma (AC) of the pancreas. ASC was confirmed in 17 (3.7%) of these patients. We analyzed the clinicopathological characteristics and survival of these 17 patients in comparison with those of patients with AC of the pancreas. Results: The operative procedures performed were pancreaticoduodenectomy (n = 6) and distal pancreatectomy (n = 11). Seven (41.2%) of the 17 patients underwent combined organ resection. R0 resection was achieved in 16 (94.1%) patients. The 5-year overall survival (OS) rate and MST were 40.3% and 20.9 months, respectively. A squamous component of ≥ 60% (P = 0.001) and R1 resection (P < 0.001) were significantly associated with poor OS for patients with ASC Conclusion: This study revealed longer survival and a higher R0 resection rate after aggressive combined resection in our ASC patients than those in previous studies. Although this was only a small series, our findings suggest that local control with aggressive resection may be an effective treatment protocol for ASC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PANCREAS
*PANCREATECTOMY
*CARCINOMA
Subjects
Details
- Language :
- English
- ISSN :
- 09411291
- Volume :
- 49
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Surgery Today
- Publication Type :
- Academic Journal
- Accession number :
- 138725398
- Full Text :
- https://doi.org/10.1007/s00595-019-01807-8