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The effects of a 5-hydroxytryptamine 1A receptor gene polymorphism on the clinical response to fluvoxamine in depressed patients.
- Source :
-
Pharmacogenomics Journal . 2004, Vol. 4 Issue 4, p283-286. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2004
-
Abstract
- We investigated the effects of a 5-hydroxytryptamine (5-HT) 1A receptor gene polymorphism on the clinical response to fluvoxamine (FLV) in 65 depressed outpatients who gave written consent to participate in the study. Patients visited every 2 weeks after the first examination until the week 12 end point and were evaluated by the 17-item Hamilton Rating Scale for Depression (HAM-D-17) at each visit. FLV dose was changed in response to their clinical symptoms. The Gly272Asp polymorphism of the 5-HT1A receptor gene was identified by a PCR method. The subjects with the Asp allele had a significantly higher % reduction in the HAM-D-17 score than those with the Gly/Gly genotype at week 2 (P=0.009), week 6 (P=0.036), and week 12 (P=0.031). There was a significant difference in the genotype distribution between the responders and nonresponders. These results suggest that the Gly272Asp polymorphism of the 5-HT1A receptor gene may predict the response to FLV.The Pharmacogenomics Journal (2004) 4, 283-286. doi:10.1038/sj.tpj.6500256 Published online 18 May 2004 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1470269X
- Volume :
- 4
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Pharmacogenomics Journal
- Publication Type :
- Academic Journal
- Accession number :
- 13868030
- Full Text :
- https://doi.org/10.1038/sj.tpj.6500256