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A new phenothiazine-based sensor for highly selective, ultrafast, ratiometric fluorescence and colorimetric sensing of Hg2+: Applications to bioimaging in living cells and test strips.
- Source :
-
Journal of Photochemistry & Photobiology A: Chemistry . Nov2019, Vol. 384, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
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Abstract
- • Novel phenothiazine-based colorimetric and ratiometric fluorescent sensor PPM for Hg2+ is synthesized. • PPM shows high selectivity and low detection limit of 12.5 nM in a wide pH range. • The response time of PPM for Hg2+ is within 1 min and suitable for ultrafast detection of Hg2+. • PPM for Hg2+ shows good applicability for paper/TLC-based "naked-eye" colorimetric assay. • PPM was used for fluorescence imaging of Hg2+ in living cells. A new phenothiazine-based sensor PPM was successfully designed and synthesized, which shows highly selective, ultrafast, naked-eye colorimetric and turn-on ratiometric fluorescence sensing of Hg2+ on the basis of the ICT from phenothiazine to aldehyde. Upon addition of Hg2+, obvious blue fluorescence at 455 nm decreased while green fluorescence at 528 nm enhanced, which exhibits ratiometric fluorescent turn-on response along with a "naked-eye" color change from pale-blue to bright-green. The PPM for highly sensing of Hg2+ with a quite low detection limit (12.5 nM) and a wide pH application range. The sensing mechanism proved to be the Hg2+-triggered thioacetal deprotection reaction was confirmed. Importantly, PPM was successfully employed for highly selective detecting and imaging of Hg2+ in living cells, as well as on paper/TLC-based "naked-eye" colorimetric assay. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMORECEPTORS
*FLUORESCENCE
*DETECTORS
*DETECTION limit
*CELLS
*RHODAMINES
Subjects
Details
- Language :
- English
- ISSN :
- 10106030
- Volume :
- 384
- Database :
- Academic Search Index
- Journal :
- Journal of Photochemistry & Photobiology A: Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 138499388
- Full Text :
- https://doi.org/10.1016/j.jphotochem.2019.112036