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Epidemiology and risk factors for carbapenem-resistant Enterobacteriaceae colonisation and infections: case-controlled study from an academic medical center in a southern area of China.
- Source :
-
Pathogens & Disease . Jun2019, Vol. 77 Issue 4, pN.PAG-N.PAG. 1p. 4 Charts. - Publication Year :
- 2019
-
Abstract
- OBJECTIVE While the emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) and related infections pose serious threats to global public health, the epidemiology and associated risk factors remain poorly understood and vary by geography. METHODS In a case-controlled retrospective study, we examined the prevalence, patient background and risk factors for CRE colonisation and infections, and all patient-derived CRE from January 2015 to January 2017. Isolated carbapenem-susceptible Enterobacteriaceae (CSE) from 2875 enrolled patients were randomly selected during the study. RESULTS CRE colonisation and infections detection rates were 47/2875 (1.6%). Respiratory tract specimens were most frequently seen in 20/47 (42.6%) cases. Klebsiella pneumoniae was the main isolate in 35/47 (74.5%) CRE. As for carbapenemase, KPC-2-producing bacteria was most frequently detected in 38/47 (80.9%) Enterobacteriaceae. No underlying conditions (P  = 0.004), pulmonary diseases (P  = 0.018) and no antibiotics used prior to culture within 30 days (P  < 0.001) were statistically significant between the CRE and CSE groups. CONCLUSION Klebsiellapneumoniae was the main isolate of CRE. The bla KPC-2 was the predominant CRE gene. Underlying conditions especially pulmonary diseases and antibiotics used prior to culture within 30 days represented key risk factors for acquisition of CRE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2049632X
- Volume :
- 77
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Pathogens & Disease
- Publication Type :
- Academic Journal
- Accession number :
- 138460310
- Full Text :
- https://doi.org/10.1093/femspd/ftz034