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The Effects of Anti-IL-23p19 Therapy on Atherosclerosis Development in ApoE−/− Mice.
- Source :
-
Journal of Interferon & Cytokine Research . Sep2019, Vol. 39 Issue 9, p564-571. 8p. - Publication Year :
- 2019
-
Abstract
- The aim of this study is to detect the dynamic expression of interleukin-23 (IL-23) in ApoE−/− mice at different ages and to further examine the effects of anti-IL-23 therapy on atherosclerosis development. The levels of IL-23 in the sera, aortas, and lymph nodes of ApoE−/− mice were significantly increased compared with those of age-matched controls at 8, 12, 16, 20, and 24 weeks of age. Then, 12-week-old ApoE−/− mice were intraperitoneally injected with anti-IL-23p19 neutralizing antibodies, isotype controls, and phosphate-buffered saline for 8 weeks. The proinflammatory and anti-inflammatory mediators in atherosclerotic aortas, plaque areas, plaque necrotic cores, and the contents of major inflammatory cells in plaques were subsequently determined. The results showed that anti-IL-23p19 treatment significantly decreased the expression of IL-17A, IL-6, and TNF-α in the aortas of ApoE−/− mice, but had no obvious effect on the plaque area, plaque necrotic core, or content of major inflammatory cells in atherosclerotic plaques. Although anti-IL-23p19 therapy reduces the expression of several proinflammatory cytokines, it does not significantly suppress the progression of atherosclerosis in ApoE−/− mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATHEROSCLEROTIC plaque
*ATHEROSCLEROSIS
*MICE
*INTERLEUKIN-23
*LYMPH nodes
Subjects
Details
- Language :
- English
- ISSN :
- 10799907
- Volume :
- 39
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Interferon & Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 138431730
- Full Text :
- https://doi.org/10.1089/jir.2019.0050