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Comparison of the Efficacy of Amniotic Membrane Transplantation, Topical Water-Based Propolis Extract, Corticosteroid and Antibiotic Use in Different Combinations on Subacute Corneal Alkali Burns in Rabbits.
- Source :
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Kafkas Universitesi Veteriner Fakultesi Dergisi . Nov/Dec2019, Vol. 25 Issue 6, p825-833. 9p. - Publication Year :
- 2019
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Abstract
- Investigation of the superiority of the usage of propolis extract, amniotic membrane transplantation, corticosteroid and antibiotic both separately and in different combinations was aimed. A total of 40 (20 male, 20 female) New Zealand breed rabbits weighing 2.5-3.0 kg were used in the study. The rabbits were divided into 5 groups on day 7 of alkali burn injury. Amniotic membrane transplantation was applied to 3 groups and each one of these 3 groups had different local medications as 1% water-based propolis extract (AMN+PRP), dexamethasone and tobramycin (AMN+AC) and only tobramycin (AMN+A). The other two groups, which were not performed amniotic membran transplantation, were either treated with propolis (PRP) or left as a control. The defect area results obtained from AMN+PRP group were lower than AMN+A group, and both AMN+PRP and control group at the day 9 and day 14, respectively (P=0.05). In the measurements made after the second week, AMN+PRP group showed significantly better results in all weeks in terms of defect area (P=0.05). Corneal thickness was found to be lower in all groups treated with amniotic membrane than in the other groups (P<0.05). This study aimed to find treatment effectiveness of combining the amniotic membrane with propolis, especially as an anti-inflammatory agent comparing to corticosteroids, and it was decided the outcomes can be improved on the further studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13006045
- Volume :
- 25
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Kafkas Universitesi Veteriner Fakultesi Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 138407448
- Full Text :
- https://doi.org/10.9775/kvfd.2019.21976