Are drug intradermal tests dangerous to explore cross‐reactivity and co‐sensitization in DRESS?

Dear Editor, Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a severe cutaneous adverse drug reaction, for which allergological explorations are poorly codified. In six patients, (patients 5, 7, 8, 9, 13 and 14) (43%), delayed IDTs were positive identifying culprit drugs or sensitization to additional drugs. Drug patch tests and IDTs were well tolerated in all patients, including the four patients who had IDTs with the culprit drugs (patients 5, 8, 9 and 14). [Extracted from the article]