联合检测血清糖类抗原标志物在女性绝经前后卵巢浆液性 癌诊断中的价值

Ojective: To investigate the values of combined detection of serum carbohydrate antigen markers in the diagnosis of ovarian serous carcinoma in women before and after menopause. Methods: Used a retrospective study, from August 2016 to February 2018 60 patients with ovarian serous carcinoma before and after menopause (canceration group) and 60 healthy subjects before and after menopause (health control group) were selected, the serum levels of CEA, HE4 and CA125 were detected, and their correlation with clinicopathological features and follow-up prognosis was analyzed. Results: The levels of serum CEA, HE4, CA125 and positive expression rate in the canceration group were significantly higher than those in the healthy control group (P<0.05). Among the 60 patients in the carcinogenesis group, with the increase of pathological stage, reduction of differentiation, lymph node metastasis and mortality, the positive expression rate of serum CEA, HE4 and CA125 increased significantly, the difference was statistically significant (P<0.05). In the 120 cases, there were 54 cases of ovarian serous carcinoma were combined, the sensitivity and specificity of combined diagnosis were 90.0% and 100.0%, respectively. Conclusion: The levels of serum carbohydrate antigen markers CEA, HE4 and CA12 in premenopausal and postmenopausal women with ovarian serous carcinoma were all increased, which may serve as a reference index for the diagnosis and prognosis prediction of ovarian serous carcinoma in premenopausal and postmenopausal women. [ABSTRACT FROM AUTHOR]