Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following Herpes Simplex Virus Encephalitis in a Pediatric Patient.

Highlights from the article: The association between HSE and anti-N-methyl-d-aspartate receptor encephalitis has been well recognized,[[5]] whereas few data are currently available on autoimmune GFAP astrocytopathy. Two adult patients have been documented with GFAP astrocytopathy following viral encephalitides - one following HSE[3] and the other following varicella zoster encephalitis.[1] It is reasonable to test for GFAP antibody along with other prevalent autoantibodies when autoimmune meningoencephalitis is suspected as a sequela of viral encephalitides. 6 F. Leypoldt, M.J. Titulaer, E. Aguilar, Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report, Neurology, 81, 2013, 1637-1639Leypoldt F, Titulaer MJ, Aguilar E, et al.