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P139 Dilution studies establish hla donor-specific antibodies as a predictive biomarker for selection of amr treatment in lung transplant recipients.

Authors :
Timofeeva, Olga A.
Carney, Kevin
Choe, Jason
Yoon, Edward
Alsammak, Mohamed
Geier, Steven S.
Brown, James
Au, Jenny
Cordova, Francis
Shigemura, Norihisa
Toyoda, Yoshiya
Shenoy, Kartik
Mamary, Albert
Criner, Gerald
Source :
Human Immunology. Sep2019 Supplement, Vol. 80, p161-161. 1p.
Publication Year :
2019

Abstract

Highlights from the article: Antibody-mediated rejection (AMR) caused by HLA donor-specific antibodies (DSA) is an important cause of graft failure after lung transplantation. To test whether high level DSAs could be treated with more aggressive protocol, three patients with strong DSA who needed AMR treatment underwent 4 double TPE sessions with bortezomib and IVIG as previously described by Patel et al. for pre-transplant desensitization.

Details

Language :
English
ISSN :
01988859
Volume :
80
Database :
Academic Search Index
Journal :
Human Immunology
Publication Type :
Academic Journal
Accession number :
138271056
Full Text :
https://doi.org/10.1016/j.humimm.2019.07.192