The efficacy of computer-based cognitive training for executive dysfunction in schizophrenia.

• Persons with schizophrenia exhibit deficits in various aspects of executive function - in particular, the aspects dependent on and independent of speed of information processing and high executive processing. • The use of computer-based training alongside pharmacological treatment may be more effective at improving these deficits - especially in cognitive flexibility dependent on speed of information processing and problem solving - than pharmacological treatment alone. • The efficacy of the above-mentioned computer techniques in increasing speed of information processing has not been demonstrated. The purpose of this study was to assess the effect of computer-based cognitive training on executive dysfunction in patients with schizophrenia. Sixty-five patients with schizophrenia were randomly assigned to a training group (n = 33) or a non-training group (n = 32), and compared in terms of executive performance to a healthy control group (n = 33). Executive function was assessed using the Trail Making Test, the Stroop Color and Word Test, and the Wisconsin Card Sorting Test (computer version). Cognitive training was performed using RehaCom software over a course of 16 individual sessions. Primary outcomes were training (performance at three different timepoints) and neuropsychological components (flexibility and cognitive inhibition, high executive processing, and processing speed). In both clinical groups, all aspects of executive function were found to be deficient. In the patient training group, the use of computer-based training alongside pharmacological treatment was more effective in terms of cognitive improvement than pharmacological treatment alone. However, there was no significant effect of cognitive training on processing speed. Cognitive training in schizophrenia patients was effective at improving several aspects of executive function, but did not improve processing speed. [ABSTRACT FROM AUTHOR]