Back to Search
Start Over
Two-component ratiometric sensor for Cu2+ detection on paper-based device.
- Source :
-
Analytical & Bioanalytical Chemistry . Sep2019, Vol. 411 Issue 23, p6165-6172. 8p. - Publication Year :
- 2019
-
Abstract
- The copper(II) ion (Cu2+) has played an indispensable role in diverse kinds of functional physiological processes of organisms, which has become of growing interest. Despite the fact that numerous Cu2+ test papers using fluorescent probes have been fabricated, sensors featuring the ratiometric property that integrates quenched probes and an inner standard dye are rarely reported. Herein, a two-component ratiometric sensor in a paper-based device is proposed to realize highly selective Cu2+ detection. To overcome shortcomings such as low signal-to-noise ratio and incorrect response of the quenching probe, a novel BODIPY-based turn-off probe (P2017) is designed and introduced into the paper-based device with better water solubility and selectivity for Cu2+ detection. Furthermore, a reference dye (B001), exhibiting an emission at 690 nm when the excitation wavelength is 480 nm, is also introduced into the paper-based device. These two components can enhance the quality of the signal as P2017 is sensitively quenched by Cu2+, while B001 with a photostable property, serving as an internal benchmark, is unable to react with Cu2+. The results indicated that the two components provided a new concept for optimizing paper-based device fabrication and developing accurate, simple, and inexpensive Cu2+ detection methods, which could be potentially applied to monitor human health and the environment in remote areas. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COPPER ions
*FLUORESCENT probes
*DETECTORS
*SIGNAL-to-noise ratio
*HUMAN ecology
Subjects
Details
- Language :
- English
- ISSN :
- 16182642
- Volume :
- 411
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Analytical & Bioanalytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 138200806
- Full Text :
- https://doi.org/10.1007/s00216-019-02007-6