Spectrophotometric estimation of sulfadiazine in pharmaceutical preparation by diazotization coupling reaction.

Aselective, accurate and rapid spectrophotometric method was development for estimation sulfadiazine drug depended on azo-Coupling reaction between SDZ and 1,2-phenylenediamine for purpose formation product color intense with maximumwave length at 458 nm. The procedure circumstance were completely and perfectly. The linearity is obeyed (0.1-11 ppm) and Molar Absorptivities 2.933x104 l/mol cm. Sandll sensitivities was [ 0.008]μg/cm², Detection limit 0.0456 μg ml-1 with LOQ 0.1523μg ml-1. In a progression the examined method employed to obtainable quantities of SDZ in a dosage forms. [ABSTRACT FROM AUTHOR]