运动性软骨损伤的问题及潜在性治疗方案.

BACKGROUND: Articular cartilage damage is very common in exercise and is mainly caused by chronic joint stress or acute traumatic sprain, which often leads to progressive damage of joint function and limits the participation of related exercise and exercise. The existing articular cartilage repair technique can repair articular cartilage damage caused by high impact exercise, but this treatment cannot produce normal articular cartilage, which limits the success rate and durability of cartilage repair.OBJECTIVE: To review the problems and potential treatment progress in the treatment of sports cartilage injury at home and abroad in recent years.METHODS: CNKI, VIP, WanFang, PubMed, Google Scholar, and Web of Science databases were retrieved using the keywords of "cartilage,exercise, review, back pain, treat" in Chinese and English, respectively, focusing on the selection of literature published in the past 5 years. A total of 627 articles were searched, and 44 eligible articles were included based on inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1) The goal of treating sports articular cartilage injury is to alleviate pain, improve knee function, and most importantly, to restore athletes to the level of exercise before injury.(2) At present, some surgical techniques have been implemented to achieve variable and durable articular cartilage repair, allowing athletes to return to sports and exercise. However, surgery does not produce completely normal hyaline cartilage.(3) It has been found that cartilage progenitor cells exist in articular cartilage, and have migration behavior, multi-differentiation ability and colony formation ability. Because mechanical injuries with different characteristics and intensities simulate cartilage progenitor cells, so apoptotic cells release inducers, thus differentiating into chondroblasts to repair injured cartilage.(4)Thereafter, bioprinting of specific osteochondral structures rich in cartilage progenitor cells to replace damaged joints remains a potential strategy in the future. [ABSTRACT FROM AUTHOR]