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Woad extract containing cream improves significantly dry, irritated, and pruritic skin.
- Source :
-
Dermatologic Therapy . Jul2019, Vol. 32 Issue 4, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
-
Abstract
- Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating scale [NRS], dynamic pruritus score [DPS]), skin dryness (itch‐controlled days [ItchCD], overall dry skin [ODS]), transepidermal water loss (TEWL), skin hydration and quality of life (5PLQ, DLQI). All sensorial characteristics were well perceived (>4), with tolerability (4.77 ± 0.47) and no negative skin feelings (4.73 ± 0.74) achieving the highest scores (0–5 scale). Dry skin and symptoms improved significantly (p < .001) for all variables: NRS (from 4.8 ± 1.74 to 1.83 ± 2.18), ItchCD (from 8.23 ± 4.40 to 4.81 ± 4.07), ODS (from 1.80 ± 0.85 to 0.65 ± 0.65), hydration (23.33 ± 1.33 to 40.70 ± 1.86), and quality of life (5PLQ: from 7.12 ± 4.25 to 4.24 ± 3.67; DLQI: from 5.29 ± 4.79 to 3.00 ± 3.98). The DPS revealed a moderate antipruritic effect. The TEWL decreased slightly (p = .511). No side effects were reported. The study suggests that, the cream is effective, and well tolerated in treating dry, irritated, and pruritic skin. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SKIN
*OINTMENTS
*SKIN physiology
*DRUG side effects
*EXTRACTS
Subjects
Details
- Language :
- English
- ISSN :
- 13960296
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Dermatologic Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 137967559
- Full Text :
- https://doi.org/10.1111/dth.12939