Cyclic diarylheptanoids deoxycymodienol and isotedarene A from Zostera marina (Zosteraceae).

• Zostera marina L. (Zosteraceae) yielded the cyclic diarylheptanoid cymodienol. • Also a previously undescribed diaryheptanoid, isotedarene A was found. • This compound is closely related to tedarene A, previously described from a sponge. • Structures were established by MS and extensive 1D and 2D NMR experiments. A first phytochemical investigation of apolar natural products of the seagrass Zostera marina L. (Zosteraceae) yielded cymodienol, a cyclic diarylheptanoid so far only known from the seagrass Cymodocea nodosa (Ucria) Asch. (Cymodoceaceae) and a previously undescribed diaryheptanoid, isotedearene A, which is closely related to tedarene A, a natural product previously described from the neotropic sponge Tedania ignis (Duchassaing & Michelotti, 1864) (Tedaniidae). Structures were established by mass spectrometry and extensive 1D and 2D NMR experiments. [ABSTRACT FROM AUTHOR]