43RARE COPY NUMBER VARIATIONS ARE ASSOCIATED WITH POORER COGNITION IN SCHIZOPHRENIA.

Highlights from the article: B Background: b Rare copy number variations (CNVs) are associated with increased risk of neuropsychiatric disorders and lower cognitive ability in healthy individuals. B Results: b In CardiffCOGS, individuals with a schizophrenia CNV (N=8) performed over one standard deviation below cases without a schizophrenia CNV (N=471) on the MATRICS composite z-score ( =-1.16., 95%CI = -2.06 to -0.25, p=0.011). B Discussion: b In the largest combined schizophrenia sample to date with cognition data, we have demonstrated that individuals with the disorder who are carriers of schizophrenia CNVs display clinically important levels of cognitive impairment.