EPIGENOME-WIDE ASSOCIATION STUDY META-ANALYSIS OF AGGRESSIVE BEHAVIOR.

Highlights from the article: B Abstract: b Aggressive behavior emerges early in childhood, peaking between the age of two and four, which is considered to be a normal aspect of development (Alink et al. 2006). Life conditions may impact on genetic pathways involved in aggressive behavior by inducing changes to epigenetic modifications, such as DNA methylation, that regulate gene expression (Provencal et al. 2015). The mean age at phenotypic assessment ranges from 6 to 72 and multiple instruments were used to assess aggressive behavior or conduct problems, such as the Child Behavior Check List (CBCL), Strength and Difficulty Questionnaire (SDQ), Multidimensional Peer Nomination Inventory (MNPI), ASEBA adult self-report (ASR), DSM Conduct Disorder Symptom Scale, Multidimensional Personality Questionnaire (MPQ), Temperament and Character Inventory (TCI), and the NEO personality questionnaire.