Back to Search
Start Over
Blood Schizonticidal Activity and Safety of Tafenoquine When Administered as Chemoprophylaxis to Healthy, Nonimmune Participants Followed by Blood Stage Plasmodium falciparum Challenge: A Randomized, Double-blind, Placebo-controlled Phase 1b Study.
- Source :
-
Clinical Infectious Diseases . Aug2019, Vol. 69 Issue 3, p480-486. 7p. - Publication Year :
- 2019
-
Abstract
- Background Tafenoquine was recently approved for chemoprophylaxis of malaria. Its specific activity against liver and blood stages of Plasmodium species has been separately characterized in animals but not in humans. Methods In this randomized, double-blind, placebo-controlled study, 16 malaria-naive, glucose-6-phosphate dehydrogenase–normal participants aged 20–42 years received tafenoquine chemoprophylaxis prior to challenge with blood stage Plasmodium falciparum. Participants were randomly assigned to either tafenoquine (n = 12) or placebo (n = 4) and took blinded study medication (single 200-mg dose) on days 1, 2, 3, and 10, followed by intravenous inoculation with approximately 2800 P. falciparum parasitized erythrocytes on day 13. The primary endpoint was the number of participants requiring rescue treatment with artemether/lumefantrine due to the onset of parasitemia as determined by quantitative polymerase chain reaction. Results None of the 12 participants who received tafenoquine developed parasitemia, whereas all placebo participants developed parasitemia (P =.0005). Two cases of mild hemoglobin decrease and a single case of mild hyperbilirubinemia occurred in the tafenoquine group. Conclusions Tafenoquine chemoprophylaxis is safe and effective in preventing malaria in healthy nonimmune participants challenged with blood stage P. falciparum. Clinical Trials Registration Australian and New Zealand Clinical Trials Registry (ANZCTR): ACTRN12617000102370. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BACTEREMIA prevention
*MALARIA prevention
*ERYTHROCYTES
*ANIMAL experimentation
*ANTIMALARIALS
*HYPERBILIRUBINEMIA
*INTRAVENOUS therapy
*MALARIA
*OXIDOREDUCTASES
*PATIENT safety
*POLYMERASE chain reaction
*QUINOLINE
*RANDOMIZED controlled trials
*TREATMENT effectiveness
*BLIND experiment
*PARASITEMIA
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 69
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 137702667
- Full Text :
- https://doi.org/10.1093/cid/ciy939