Undersampled MR image reconstruction using an enhanced recursive residual network.

• ERRN is based on a recursive residual network and enhanced by user-designed functional modules, i.e. high-frequency feature guidance, application-specific error-correction. • The feature guidance is designed to predict the underlying anatomy based on image a priori, playing a complementary role to residual learning. • An application-specific error-correction is adapted to include different reconstruction tasks, i.e. data consistency for CS-MRI and back projection for SR-MRI. • ERRN can achieve good performance on undersampled MRI reconstruction with reduced overfitting in generalization. When using aggressive undersampling, it is difficult to recover the high quality image with reliably fine features. In this paper, we propose an enhanced recursive residual network (ERRN) that improves the basic recursive residual network with a high-frequency feature guidance, an error-correction unit and dense connections. The feature guidance is designed to predict the underlying anatomy based on image a priori learned from the label data, playing a complementary role to the residual learning. The ERRN is adapted for two important applications: compressed sensing (CS) MRI and super resolution (SR) MRI, while an application-specific error-correction unit is added into the framework, i.e. data consistency for CS-MRI and back projection for SR-MRI due to their different sampling schemes. Our proposed network was evaluated using a real-valued brain dataset, a complex-valued knee dataset, pathological brain data and in vivo rat brain data with different undersampling masks and rates. Experimental results demonstrated that ERRN presented superior reconstructions at all cases with distinctly restored structural features and highest image quality metrics compared to both the state-of-the-art convolutional neural networks and the conventional optimization-based methods, particularly for the undersampling rate over 5-fold. Thus, an excellent framework design can endow the network with a flexible architecture, fewer parameters, outstanding performances for various undersampling schemes, and reduced overfitting in generalization, which will facilitate real-time reconstruction on MRI scanners. [ABSTRACT FROM AUTHOR]