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Scolopendra subspinipes mutilans L. Koch Ameliorates Rheumatic Heart Disease by Affecting Relative Percentages of CD4+CD25+FoxP3 Treg and CD4+IL17 T Cells.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 7/14/2019, p1-12. 12p. 2 Diagrams, 5 Charts, 4 Graphs. - Publication Year :
- 2019
-
Abstract
- Scolopendra subspinipes mutilans L. Koch. (SSLK) helps reduce the risk of coronary heart disease (CHD) but its effects on rheumatic heart disease (RHD) patients remain unclear. 80 RHD patients were recruited and randomly assigned into SG (to receive SSLK treatment) and CG (to receive placebo) groups, and the intervention lasted for 3 months. The following cardiac indexes were measured, including mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), blood lactate, fatigue, shortness of breath, palpitation, and chest pain. ELISA kits were used to analyze creatine kinase isoenzyme (CK-MB), serum troponin T (cTnT), CRP, IL-1β, IL-6, and TNF-α, malondialdehyde (MDA), and superoxide dismutase (SOD). Relative percentages of CD4+CD25+FoxP3 regulatory (Treg) and CD4+IL-17 T cells were measured using flow cytometry. After 3-month therapy, SSLK intervention improved MAP, HR, CVP, fatigue, palpitation, and shortness breath of CHD patients, reduced the levels of blood lactate, CK-MB, cTnT, CRP, IL-1β, IL-6, TNF-α, MDA, and increased SOD level (p < 0.05). Meanwhile, SSLK treatment increased the percentages of CD4+CD25+FoxP3 Treg cells and reduced relative percentages of CD4+IL-17 T cells in a dose-dependent way (p < 0.05). Relative percentage of CD4+CD25+FoxP3 Treg cells had negative relationship while CD4+IL17 T cells had positive relationship with CK-MB, cTnT, CRP, and TNF-a (p < 0.01). SSLK ameliorated RHD by affecting the balance of CD4+CD25+FoxP3 Treg and CD4+IL17 T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of venom
*ANALYSIS of variance
*ARTERIES
*BLOOD circulation
*BLOOD pressure
*C-reactive protein
*CELLULAR signal transduction
*CENTRAL venous pressure
*CHEST pain
*CHI-squared test
*STATISTICAL correlation
*CREATINE kinase
*CYTOKINES
*DYSPNEA
*ENZYME-linked immunosorbent assay
*FATIGUE (Physiology)
*FLOW cytometry
*HEART beat
*INTERLEUKINS
*ISOENZYMES
*LACTATES
*CHINESE medicine
*RHEUMATIC heart disease
*STATISTICAL sampling
*SUPEROXIDE dismutase
*T cells
*T-test (Statistics)
*TUMOR necrosis factors
*MALONDIALDEHYDE
*BODY mass index
*RANDOMIZED controlled trials
*DATA analysis software
*TROPONIN
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 137465219
- Full Text :
- https://doi.org/10.1155/2019/4674190