高黏度骨水泥椎体成形治疗骨质疏松性椎体压缩骨折.

BACKGROUND: Studies have confirmed that the use of high viscosity bone cement for vertebroplasty can significantly reduce the risk of bone cement leakage. OBJECTIVE: To study the clinical effect of high viscosity bone cement vertebroplasty in the treatment of osteoporotic vertebral compression fractures. METHODS: From October 2014 to February 2017, 200 patients with osteoporotic vertebral compression fractures were enrolled at the Department of Osteopathy, Hengshui City People’s Hospital, including 82 males and 118 females, aged 60-82 years. The patients were randomly divided into two groups: trial group (n=100, high viscosity bone cement for vertebroplasty) and control group (n=100, low viscosity bone cement for vertebroplasty), and the bone cement leakage intraoperatively was recorded. The Visual Analog Scale score, low back pain dysfunction index score and SF-36 score were used to evaluate the improvement of clinical symptoms at baseline and 3 months and 1 year after surgery. The height recovery and Cobb angle of the injured vertebrae were evaluated by imaging examination. The study was approved by the Ethics Committee of Harrison Internal Peace Hospital, approval number: 2015-2-003. RESULTS AND CONCLUSION: (1) The incidence of bone cement leakage in the trial group was significantly lower than that in the control group (10%, 27%, P=0). (2) At 3 months and 1 year after surgery, the Visual Analog Scale score and low back pain dysfunction index scores in both groups were significantly lower than those at baseline, and the SF-36 score was significantly higher than that at baseline (P < 0.05). All above scores showed no significant difference between two groups (P > 0.05). (3) The height and Cobb angle of the injured vertebrae in both groups were significantly improved compared with those at baseline (P < 0.05), and there was no significant difference in the height and Cobb angle of the injured vertebrae between two groups (P > 0.05). (4) These results indicate that both high viscosity bone cement and low viscosity bone cement vertebroplasties have good clinical effect in the treatment of osteoporotic vertebral compression fracture, but the risk of bone cement leakage is low when high viscosity bone cement is used. [ABSTRACT FROM AUTHOR]