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Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study.
- Source :
-
American Journal of Clinical Pathology . Jun2019, Vol. 151 Issue 6, p613-621. 9p. 1 Color Photograph, 1 Black and White Photograph, 6 Charts, 1 Graph. - Publication Year :
- 2019
-
Abstract
- <bold>Objectives: </bold>Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).<bold>Methods: </bold>A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases.<bold>Results: </bold>The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively.<bold>Conclusions: </bold>The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELLULAR pathology
*BENIGN tumors
*NEEDLE biopsy
*SALIVARY glands
Subjects
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 151
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 137290965
- Full Text :
- https://doi.org/10.1093/ajcp/aqz006