Back to Search
Start Over
Differential Risk of ST-Segment Elevation Myocardial Infarction in Male and Female Smokers.
- Source :
-
Journal of the American College of Cardiology (JACC) . Jul2019, Vol. 73 Issue 25, p3259-3266. 8p. - Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>Smoking is a well-documented risk for acute ST-segment elevation myocardial infarction (STEMI). The differential effect between sexes has yet to be quantified.<bold>Objectives: </bold>The purpose of this study was to differentiate the effect of smoking on increased risk of STEMI between sexes.<bold>Methods: </bold>For this retrospective ecological cohort study, all patients at a U.K. tertiary cardiothoracic center who presented between 2009 and 2014 with acute STEMI were combined with population data to generate incidence rates of STEMI. Age-standardized incidence rate ratios (IRRs) using the Poisson distribution were calculated comparing STEMI rates between smokers and nonsmokers stratified by sex and 3 age groups (18 to 49, 50 to 64, and >65 years).<bold>Results: </bold>A total of 3,343 patients presented over 5,639,328 person-years. Peak STEMI rate for current smokers was in the 70 to 79 years age range for women (235 per 100,000 patient-years) and 50 to 59 years (425 per 100,000 patient-years) in men. Smoking was associated with a significantly greater increase in STEMI rate for women than men (IRR: 6.62; 95% confidence interval [CI]: 5.98 to 7.31, vs. 4.40; 95% CI: 4.15 to 4.67). The greatest increased risk was in women age 18 to 49 (IRR: 13.22; 95% CI: 10.33 to 16.66, vs. 8.60; 95% CI: 7.70 to 9.59 in men). The greatest risk difference was in the age 50 to 64 years group, with IRR of 9.66 (95% CI: 8.30 to 11.18) in women and 4.47 (95% CI: 4.10 to 4.86) in men.<bold>Conclusions: </bold>This study quantifies the differential effect of smoking between sexes, with women having a significantly increased risk of STEMI than men. This information encourages continued efforts to prevent smoking uptake and promote cessation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYOCARDIAL infarction
*AGE groups
*POISSON distribution
*AGE differences
*GENDER
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 73
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 137213326
- Full Text :
- https://doi.org/10.1016/j.jacc.2019.03.525