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Beryllium inhibits apoptosis via mitochondria in beryllium-induced lung disease in the rat.
- Source :
-
Experimental Lung Research . Apr-May2019, Vol. 45 Issue 3/4, p92-100. 9p. - Publication Year :
- 2019
-
Abstract
- Objective: We aimed to determine whether beryllium toxicity was associated with mitochondria apoptosis pathway in SD rats. Methods: Thirty-two SD rats were given an intratracheal instillation dose of 10 g/l beryllium oxide (0.5 ml per rat). Additional 32 rats were given an intratracheal instillation dose of 0.9% normal saline (0.5 ml per rat). The percentage of apoptosis, mitochondrial membrane potential, the expression level of apoptosis related genes and proteins, including bcl2, Bax and Caspase-3 were detected. Results: The average of percentage of apoptosis, the expression of caspase-3, bax, and cytochrome c were decreased significantly in lung tissues from rats exposed to beryllium oxide compared to normal controls. The expression of bcl2 and ADP were increased significantly at 80 d after exposure. Conclusions: We conclude that inhibition of apoptosis by beryllium oxide involves mitochondrial apoptosis pathway in rat model of beryllium oxide-induced pulmonary disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RAT diseases
*BERYLLIUM
*APOPTOSIS inhibition
*LUNG diseases
*CYTOCHROME c
Subjects
Details
- Language :
- English
- ISSN :
- 01902148
- Volume :
- 45
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Experimental Lung Research
- Publication Type :
- Academic Journal
- Accession number :
- 137165211
- Full Text :
- https://doi.org/10.1080/01902148.2019.1621409