Response to Comment on Barbour and Feig. Metformin for Gestational Diabetes Mellitus: Progeny, Perspective, and a Personalized Approach. Diabetes Care 2019;42:396-399.

The authors offer a response to comments on their article on the progeny, perspective, and a personalized approach to metformin for gestational diabetes mellitus. Topics discussed include potential differences in offspring effects from metformin in an intrauterine environment of maternal nutrient excess, maternal obesity's higher risk of placental insufficiency and restrictive nutrition, and the continuing discernment on childhood effects when metformin is given to mothers.