Detection of nucleotide sequences capable of forming non-canonical DNA structures: Application of automata theory.

• Nucleotide sequences capable to form combinations of DNA non-canonical structures were detected. • Special software for molecular biologist was developed. • Minimal length of nucleotide sequences with structural polymorphism was revealed. In this study, we develop a program that allows us to reveal DNA receptors, i.e. nucleotide sequences that may form more than one non-canonical structure. The data obtained may be analysed either experimentally or using DNA banks, and refers to the coding, non-coding or promotor region of the gene. These results provide a better understanding of the role that non-canonical structures play in pathological modifications of the genetic apparatus, resulting in tumour formation or inherited disease. They also reveal the effect of single nucleotide polymorphisms on gene expression, indicate so-called "risk regions" in which the substitution of a single nucleotide may lead to increased formation of non-canonical structures, and elucidate the epigenetic mechanisms of microorganism adaptation. [ABSTRACT FROM AUTHOR]