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Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.
- Source :
-
Parkinsonism & Related Disorders . May2019, Vol. 62, p85-90. 6p. - Publication Year :
- 2019
-
Abstract
- <bold>Introduction: </bold>Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures in patients with PD.<bold>Methods: </bold>Data from 125 patients (age: 71.7 ± 6.5 years, Hoehn and Yahr: 1-3, 60.5% men) were analyzed. The MDS-UPDRS-part III was used as the gold standard of motor symptom severity. Gait and balance were quantified in the laboratory. Daily-living gait and physical activity metrics were extracted from an accelerometer worn on the lower back for 7 days.<bold>Results: </bold>In multivariate analyses, daily-living physical activity and gait metrics, laboratory-based balance, demographics and subject characteristics together explained 46% of the variance in MDS-UPDRS-part III scores. Daily-living measures accounted for 62% of the explained variance, laboratory measures 30%, and demographics and subject characteristics 7% of the explained variance. Conversely, demographics and subject characteristics, laboratory-based measures of gait symmetry, and motor symptom severity together explained less than 30% of the variance in total daily-living physical activity. MDS-UPDRS-part III scores accounted for 13% of the explained variance, i.e., <4% of all the variance in total daily-living activity.<bold>Conclusions: </bold>Our findings suggest that conventional measures of motor symptom severity do not strongly reflect daily-living activity and that daily-living measures apparently provide important information that is not captured in a conventional one-time, laboratory assessment of gait, balance or the MDS-UPDRS. To provide a more complete evaluation, wearable devices should be considered. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PARKINSON'S disease
*PHYSICAL activity
*MOTORS
*MULTIVARIATE analysis
Subjects
Details
- Language :
- English
- ISSN :
- 13538020
- Volume :
- 62
- Database :
- Academic Search Index
- Journal :
- Parkinsonism & Related Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 137074235
- Full Text :
- https://doi.org/10.1016/j.parkreldis.2019.01.022