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Long-term results of fertility-sparing treatment for early-stage cervical cancer.
- Source :
-
Gynecologic Oncology . Jul2019, Vol. 154 Issue 1, p89-94. 6p. - Publication Year :
- 2019
-
Abstract
- To evaluate the long-term outcomes of young early stage cervical cancer patients wishing to preserve their childbearing potential. Data of young (aged <40 years) patients with early stage cervical cancer were prospectively collected. All patients with stage IA2, IB1 and IB2 cervical cancer were included; they have cervical conization and pelvic node dissection performed via minimally invasive surgery. Survival outcomes were assessed with the Kaplan-Meier model. Overall, 32 patients met the inclusion criteria. Mean (SD) age of the population included was 33 (±4). According to the FIGO 2018 staging system, the stage of disease was IA2, IB1 and IB2 in 9 (28%), 21 (66%) and 2 (6%) cases, respectively. All patients included had cervical conization and laparoscopic pelvic node assessment, including systematic pelvic lymphadenectomy (N = 30, 94%) and sentinel node mapping (N = 2, 6%). In six (19%) patients the planned conservative treatment was discontinued. Median follow-up was 75 (range, 12–184) months. No recurrent disease was diagnosed among patients undergoing conservative treatment; while 2 out of 6 patients having definitive surgical or radiotherapy treatments developed recurrent disease. Five-year disease free and overall survivals were 94% and 97%, respectively. Considering reproductive outcomes, 11 (69%) out of 16 patients who attempted to conceive got pregnant. Cervical conization and pelvic nodes assessment could be considered a valid treatment modality for early-stage cervical cancer patients who are wishing to preserve their childbearing potential. • Cervical conization plus lymph node dissection is a valuable option for early-stage stage cervical cancer. • About 20% for patients initially submitted to fertility sparing procedure required radical treatments. • In case of negative margins, cervical conization guarantees a good local disease control rate. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00908258
- Volume :
- 154
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Gynecologic Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 137073166
- Full Text :
- https://doi.org/10.1016/j.ygyno.2019.04.007