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Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit.
- Source :
-
BioMed Research International . 6/13/2019, p1-8. 8p. - Publication Year :
- 2019
-
Abstract
- Background. Obesity and pregnancy increase levels of maternal oxidative stress (OS). However, little is known about the maternal, placental, and neonatal OS status. Objective. To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake. Methods. This cross-sectional study included 33 women with singleton, noncomplicated pregnancies. Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15). Dietary and clinical information was obtained by questionnaire and from clinical records. Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry. Results. Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake). Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05). Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02). Conclusion. Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn. The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLACENTA physiology
*OBESITY complications
*BIOMARKERS
*COLORIMETRY
*CORD blood
*GENE expression
*GESTATIONAL age
*IMMUNOHISTOCHEMISTRY
*INGESTION
*MAGNESIUM
*MATERNAL health services
*MEDICAL records
*NUTRITIONAL assessment
*OXIDOREDUCTASES
*PRECONCEPTION care
*PRENATAL care
*QUESTIONNAIRES
*MICRONUTRIENTS
*VITAMIN A
*MALONDIALDEHYDE
*OXIDATIVE stress
*BODY mass index
*CROSS-sectional method
*ACQUISITION of data methodology
*PREGNANCY
PREGNANCY complication risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 136960133
- Full Text :
- https://doi.org/10.1155/2019/5070453