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Effects of UK 69 578: a novel atriopeptidase inhibitor.
- Source :
-
Lancet . 9/9/1989, Vol. 334 Issue 8663, p591-593. 3p. - Publication Year :
- 1989
-
Abstract
- UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANIMAL experimentation
*ATRIAL natriuretic peptides
*CLINICAL trials
*COMPARATIVE studies
*CORONARY disease
*DOGS
*DRUG design
*DOSE-effect relationship in pharmacology
*CLINICAL drug trials
*INTRAVENOUS therapy
*RESEARCH methodology
*MEDICAL cooperation
*PROTEOLYTIC enzymes
*RATS
*RESEARCH
*TIME
*URINARY organ physiology
*EVALUATION research
*RANDOMIZED controlled trials
*BLIND experiment
*CARBOCYCLIC acids
*NEPHRECTOMY
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 01406736
- Volume :
- 334
- Issue :
- 8663
- Database :
- Academic Search Index
- Journal :
- Lancet
- Publication Type :
- Academic Journal
- Accession number :
- 136954908
- Full Text :
- https://doi.org/10.1016/s0140-6736(89)90714-9