fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate.

• The proposed kinetic model explains the trigger effect of N-acetylaspartate behavior. • Substrate inhibition is a necessary factor of N-acetylaspartate autostabilization. • N-acetylaspartate's "anti-peak" causes a wave of its hydrolysis products. A kinetic model of the process response of nervous tissue to an external signal stimulus is proposed. The model is based on the multistage and non-linear nature of the dynamic process of changes of N-acetylaspartate concentration. The existence of multiple steady states explains the trigger effect of the system. The effect of substrate inhibition for this system was studied as a necessary factor of N-acetylaspartate's autostabilization as a key metabolite in the brain. The appearance of N-acetylaspartate's "anti-peak" causes a wave of its hydrolysis products, such as aspartic acid and acetic acid. [ABSTRACT FROM AUTHOR]