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Metabolites from the marine-facultative Aspergillus sp. MEXU 27854 and Gymnoascus hyalinosporus MEXU 29901 from Caleta Bay, Mexico.

Authors :
Aparicio-Cuevas, Manuel A.
González, María del Carmen
Raja, Huzefa A.
Rivero-Cruz, Isabel
Kurina, Steven J.
Burdette, Joanna E.
Oberlies, Nicholas H.
Figueroa, Mario
Source :
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2019, Vol. 60 Issue 25, p1649-1652. 4p.
Publication Year :
2019

Abstract

• New N -methyl cyclic pentapeptide and alternariol glucoside. • Marine-facultative fungi from an unexplored area of Mexico. • Absolute configuration by spectrometric analysis and chemical degradation. • Cytotoxic, antimicrobial and phytogrowth inhibition activities. During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl 3 −MeOH extract of the marine-facultative Aspergillus sp. MEXU 27854 yielded a new N -methyl cyclic pentapeptide (1) along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative Gymnoascus hyalinosporus MEXU 29901, a new alternariol glucoside, 10 -O -[ β - d -(4-methoxyl-glucopyranosyl)]-4- O -methylalternariol (2) and known alternariol 4- O- methyl ether, alternariol and beauvericin, were isolated. The structures of 1 and 2 were established by detailed spectroscopic data, and their absolute configuration was ascertained by Marfey's analysis and HRESIMS-MS/MS data for 1 , and by chemical degradation and optical rotation analysis for 2. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00404039
Volume :
60
Issue :
25
Database :
Academic Search Index
Journal :
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :
Academic Journal
Accession number :
136840233
Full Text :
https://doi.org/10.1016/j.tetlet.2019.05.037