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The Potential Role of the Jā€Tpeak Interval in Proarrhythmic Cardiac Safety: Current State of the Science From the American College of Clinical Pharmacology and the Cardiac Safety Research Consortium.

Authors :
Vicente, Jose
Strauss, David G.
Upreti, Vijay V.
Fossler, Michael J.
Sager, Philip T.
Noveck, Robert
Source :
Journal of Clinical Pharmacology. Jul2019, Vol. 59 Issue 7, p909-914. 6p.
Publication Year :
2019

Abstract

The article highlights the role of the J-Tpeak Interval in Proarrhythmic Cardiac Safety. Topics discussed the J-Tpeak interval is the time from the end of the QRS complex to the peak of the T-wave; mentions the assessment for unanticipated electrocardiogram (ECG) effects and highlights the use of Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative to impact drug discovery, development, and therapeutic use.

Details

Language :
English
ISSN :
00912700
Volume :
59
Issue :
7
Database :
Academic Search Index
Journal :
Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
136804681
Full Text :
https://doi.org/10.1002/jcph.1411