A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts.

Authors :: Gilbert, Sophie H.
Viseur, Virginie
Clarke, Matthew L.
Source :: Chemical Communications. 6/7/2019, Vol. 55 Issue 45, p6409-6412. 4p.
Publication Year :: 2019
Abstract: High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis. [ABSTRACT FROM AUTHOR]

Subjects :: *AMINATION
*KETONES
*HYDROGENATION
*CATALYSTS
*CATALYSIS
*TERTIARY amines

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