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Porphyrin‑silver nanoparticles hybrids: Synthesis, characterization and antibacterial activity.
- Source :
-
Materials Science & Engineering: C . Sep2019, Vol. 102, p192-199. 8p. - Publication Year :
- 2019
-
Abstract
- The preparation of light-activated hybrid antibacterial agent combining the porphyrin molecules, bound to the silver nanoparticles (AgNPs) surface is reported. AgNPs were synthesized by N -methyl-2-pyrrolidone-initiated reduction without additional reducing agents. The chemical structure of protoporphyrin IX was modified with the aim to introduce thiol groups. The size distribution and shape features of AgNPs were checked using TEM and HRTEM microscopies. The introduction of thiol groups into the porphyrin was proved by IR spectroscopy. The AgNPs-porphyrin binding was performed in solution and confirmed by fluorescence quenching, Raman spectroscopy and energy-filtered transmission electron microscopy (EFTEM). The antibacterial tests were performed against S. epidermidis and E. coli upon to LED illumination and in the dark. The synergetic effect of AgNPs and porphyrin as well as light activation of the created antibacterial conjugates were observed. • The light-activated hybrid antibacterial agent combining the porphyrin and AgNPs is reported. • The chemical structure of porphyrin was modified for introduction of thiol groups, responsible for grafting to AgNPs • The antibacterial activity of prepared conjugates was tested on gram-negative and gram-positive bacterial strains. • The synergetic effect of AgNPs and porphyrin under illuminatwas observed. • The prepared hybrids show better antibacterial activity then the pristine porphyrin and AgNPs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 102
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 136690593
- Full Text :
- https://doi.org/10.1016/j.msec.2019.04.029