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Nutrition and Bipartite Metabolism of Intracellular Pathogens.
- Source :
-
Trends in Microbiology . Jun2019, Vol. 27 Issue 6, p550-561. 12p. - Publication Year :
- 2019
-
Abstract
- The host is a nutrient-rich niche for microbial pathogens, but one that comes with obstacles and challenges. Many intracellular pathogens like Legionella pneumophila, Coxiella burnetii, Listeria monocytogenes, and Chlamydia trachomatis have developed bipartite metabolism within their hosts. This style of metabolic regulation enables pathogen sensing of specific nutrients to engage them into catabolic and anabolic processes, and contributes to temporal and spatial pathogen phenotypic modulation. Not only have intracellular pathogens adapted their metabolism to the host, they have also acquired idiosyncratic strategies to exploit host nutritional supplies and intercept metabolites. Francisella tularensis and Anaplasma phagocytophilum alter host autophagy, Shigella flexneri intercepts all host pyruvate, while L. pneumophila induces host protein degradation and blocks protein translation. Strategies of pathogen manipulation of host nutrients could serve as therapeutic targets. There is a general common theme of bipartite metabolism by intracellular pathogens. Pathogens have evolved with mechanisms to override host-limited availability of nutrients. Host nutrient supplies govern pathogen virulence properties. Import of host nutrients occurs across the pathogen-containing vacuoles using host SLCs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0966842X
- Volume :
- 27
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Trends in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 136464632
- Full Text :
- https://doi.org/10.1016/j.tim.2018.12.012