IMPORTÂNCIA DO ESTRESSE OXIDATIVO NO ACIDENTE VASCULAR ENCEFÁLICO.

Stroke is a pathological process that occurs when the blood supply of the brain is interrupted, reducing or completely stopping the oxygenation and arrival of nutrients. The brain is a very attractive organ for various oxidative reactions, because it has a large amount of polyunsaturated fatty acids that are highly susceptible to peroxidation, low concentration of antioxidants and high consumption of oxygen. Molecular mechanisms are still not fully understood, but there is evidence that ROS and RNs are important actors in actions that damage brain tissue1. In this review, we will discuss the mechanisms of action of oxidative and nitrosative stress and antioxidant systems in stroke, as well as its association with disease severity and evolution. Attempts to intervene with antioxidants in the AVE will also be reported. [ABSTRACT FROM AUTHOR]