羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果分析.

Objective: To analyze the application effect of oxycodone combined with dexmedetomidine on the trigeminal nerve microvascular decompression. Methods: 86 cases of trigeminal neuralgia who were treated from January 2015 to June 2016 in our hospital were selected and divided into the control group and research group with 43 cases in each group according to the random table method. The control group was treated with oxycodone anesthesia, while the research group was treated with oxycodone jiont dexmeidine. Then the blood pressure, mean arterial pressure, serum interleukin-8(IL-8), c-reactive protein(CRP), and tumor necrosis factor-α(TNF-α) levels before and after the surgery, clinical efficacy, recurrence and adverse reactions were compared between two group. Results: Before surgery, the blood pressure, mean arterial pressure, serum IL-8, CRP, TNF-αshowed no statistically significant difference between the two groups(P>0.05). After surgery, the blood pressure, mean arterial pressure, serum IL-8, CRP, TNF-α in both groups were decreased than those before surgery and the blood pressure, mean arterial pressure of research group were higher than those of the control group, but the serum IL-8, CRP, TNF-αlevels of research group were lower than those of the control group(P<0.05). The excellent rate, recurrence rate of two groups showed no significant difference(P>0.05). There were bradycardia, itching, dizziness,nausea and vomiting in both groups, but the adverse reaction rate in research group was significantly lower than that of the study group(P<0.05). Conclusion: Oxycodone dexmedetomidine was effective in trigeminal nerve microvascular decompression, which could significantly reduce the inflammatory response and relieve the pain. [ABSTRACT FROM AUTHOR]