老年急性冠脉综合征患者血尿酸与血脂、HCY及hs-CRP水平的关系研究.

Objective: To study the relationship between blood uric acid(UA) and blood lipid, homocysteine(HCY) and hypersensitivity C reactive protein(hs-CRP) in elderly patients with acute coronary syndrome(ACS). Methods: 59 elderly patients with ACS who were treated in Chongqing Three Gorges Central Hospital from February 2014 to September 2017 were selected as the subjects, 32 patients with acute myocardial infarction(AMI) were recorded as AMI group, 27 patients with unstable angina pectoris(UAP) were recorded as UAP group.30 volunteers who were received physical examination in our hospital at the same period were selected as the control group. The levels of UA, HCY and hs-CRP and blood lipids in each group were compared, and the correlation between UA and levels of blood lipids, HCY and hs-CRP was analyzed. Results: The levels of UA, HCY and hs-CRP in AMI group and UAP group were significantly higher than those in the control group, and the AMI group was higher than that of the UAP group(P<0.05). The levels of total cholesterol(TC), triglyceride(TG) and low density lipoprotein(LDL) in AMI group and UAP group were significantly higher than those in the control group, and the AMI group was higher than that of the UAP group(P<0.05). The level of high density lipoprotein(HDL) in AMI group and UAP group was lower than that of the control group, and AMI group was lower than that of the UAP group(P<0.05). According to the analysis of the correlation of Spearman, UA of patient was positively correlated with HCY, hs-CRP, TC, TG and LDL, and which was negatively correlated with HDL(P<0.05). Conclusion: The levels of UA, HCY, hs-CRP, TC, TG and LDL in the elderly patients with ACS are all higher, the level of HDL was lower, and UA has good correlation with blood lipid, HCY and hs-CRP. It can be tried as a key monitoring target in clinical trials, so it can be applied to the diagnosis and treatment of patients with ACS. [ABSTRACT FROM AUTHOR]