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Chemical and biological properties of new sealant-use cement materials.

Authors :: Kondo, Yuki
Ito, Shuichi
Uehara, Osamu
Kurashige, Yoshihito
Fujita, Yusuke
Saito, Takashi
Saitoh, Masato
Source :: Dental Materials. May2019, Vol. 35 Issue 5, p673-685. 13p.
Publication Year :: 2019
Abstract: • More calcium ions were released from the new materials, more calcium bound to carboxyl groups in the matrix. • Biphasic release occurs before Fluoride recharge and monophasic release occurs after recharge. • New materials suppressed S. mutans growth and biofilm formation. • We produced cement by reinforcing the material properties of conventional GIC-based sealant. The aim of this study was to investigate the chemical and biological properties of newly developed bioactive cements, modified such that they are largely composed of calcium, phosphate and fluoride. We investigated whether newly developed bioactive cements have the potential to further protect surrounding hard tissue and enhance remineralization of demineralized tissue by additional ion release. We developed four types of novel GIC based on Fuji VII, modified with phosphate and fluoride and calcium. Compressive strength tests were performed following JIS T6607 methods. Ion release of calcium, phosphate and fluoride after 24 h storage were determined using atomic absorption spectroscopy, colorimetry and an ion-specific electrode. Fluoride releases and recharge were measured at 1, 3, 6, 12, 24 and 168 h. Viability was determined by colony-forming units. Inhibitions of biofilm formation and cell proliferation activity were measured. The GIC groups showed no significant differences in compressive strength after 1 and 7 days. The rates of fluoride ion release from newly developed GICs were significantly greater than those of Fuji VII, Fuji III and BS. All materials except TM can be recharged with fluoride ions. Compared with the control group, which did not release fluoride ions, all materials showed significantly stronger antibacterial effects. The newly developed GICs and BS showed less biofilm formation than Fuji VII and Fuji III. Three of four newly developed GICs modified with calcium, phosphate and fluoride ions were found to be superior to other sealant materials. [ABSTRACT FROM AUTHOR]