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Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour.
- Source :
-
Parasites & Vectors . 4/25/2019, Vol. 12 Issue 1, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
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Abstract
- Background: Natural compounds from plants are known to provide a source of anthelmintic molecules. In previous studies, we have shown that plant extracts from the plant Picria fel-terrae Lour. and particular fractions thereof have activity against the free-living nematode Caenorhabditis elegans, causing quite pronounced stress responses in this nematode. We have also shown that a fraction, designated Pf-fraction 5, derived from this plant has a substantial adverse effect on this worm; however, nothing is known about the molecular processes affected in the worm. In the present study, we explored this aspect. Results: Key biological processes linked to upregulated genes (n = 214) included 'response to endoplasmic reticulum stress' and 'lipid metabolism', and processes representing downregulated genes (n = 357) included 'DNA-conformation change' and 'cellular lipid metabolism'. Conclusions: Exposure of C. elegans to Pf-fraction 5 induces significant changes in the transcriptome. Gene ontology analysis suggests that Pf-fraction 5 induces endoplasmic reticulum and mitochondrial stress, and the changes in gene expression are either a direct or indirect consequence of this. Further work is required to assess specific responses to sub-fractions of Pf-fraction 5 in time-course experiments in C. elegans, to define the chemical(s) with potent anthelmintic properties, to attempt to unravel their mode(s) of action and to assess their selectivity against nematodes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17563305
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Parasites & Vectors
- Publication Type :
- Academic Journal
- Accession number :
- 136098322
- Full Text :
- https://doi.org/10.1186/s13071-019-3429-4