NAR KABUĞUNDAN ANTİMİKROBİYAL VE ANTİOKSİDAN AKTİVİTEYE SAHİP FENOLİK BİLEŞİKLERİN EKSTRAKSİYON KOŞULLARININ OPTİMİZASYONU.

In this study, phenolic, flavonoid, antioxidant and antimicrobial properties of pomegranate peel were investigated. The extraction conditions (temperature, time and ethanol concentration) of phenolic and flavonoid compounds obtained under 17 different conditions were optimized using the response surface method. At the end of optimization studies; for pomegranate peels; 78°C, 33% ethanol concentration 113 minutes were determined as the optimum conditions. The obtained extracts were found to have high antioxidant and antimicrobial activity. Phenolic compounds of the extracts obtained under optimum conditions were analyzed by high pressure liquid chromatography and pomegranate peels extracts were found to contain the most quercetin and epicatechin. The results support that pomegranate peels may be potentially useful as an important source of food or nonfood industries. [ABSTRACT FROM AUTHOR]