اثر حفاظتی تمرین هوازي بر اختلالهاي شناختی و عملکرد حرکتی موشهاي صحرایی نر به دنبال ایسکمی مغزي

Introduction: If the blood supply to a part of the brain is disturbed and stopped, it cannot function normally. This condition is called stroke. The aim of this study was to examine the protective effect of four-week aerobic training on cognitive impairment and motor dysfunction in male rats following cerebral ischemia. Materials and Methods: For this purpose, 27 adult male Wistar rats (weighing 230-260 g) were purchased and randomly divided into three groups: sham, ischemia and exercise training +ischemia groups. The rats in exercise group were trained to run on a treadmill five days a week for four weeks. Ischemia was induced by the occlusion of both common carotid arteries (CCA) for 20 min. The passive avoidance memory test was used to assess the memory impairments. Behavioral test including inclend plane was used to assess motor function. Data were analyzed using Kolmogroph-Smirnoff, one-way ANOVA and Scheffe posthoc tests (p<0.05). Results: Results showed that the exercise training significantly reduced the ischemia-induced disorder in the short-term memory in passive avoidance memory test (p=0.0001). However, motor function of ischemic rats did not change significantly in the inclend plane test after exercise (p= 0.137). Conclusion: In general, four weeks of aerobic training improved cognitive impairment in ischemic rats. [ABSTRACT FROM AUTHOR]