Associação do tabagismo com biomarcadores REDOX e fatores de risco cardiometabólicos em idosos.

Background: Smoking is the leading cause of preventable death worldwide, and is considered an important risk factor for cardiovascular disease (CVD). Objective: To investigate the association of smoking with sex, redox metabolism and cardiometaboic risk factors of 381 elderly from the Family Health Strategy of Porto Alegre. Method: To categorize smoking, followed by the recommendations of the Center for Disease Control (CDC). We studied the following oxidative stress markers investigated: advanced products of protein oxidation (AOPP), nitric oxide metabolites (NOx), the antioxidant capacity was measured by Ferric Reducing Ability of Plasma (FRAP). Cardiometabolic risk factors were also evaluated. Results: Regarding sex/smoking, women are more often non-smokers (P = 0.001). Former male smokers had higher concentrations of FRAP (P = 0.001), and smokers had higher concentration of NOx (0.012), lower average waist circumference-WC (P = 0.017), body mass index-BMI (P = 0.003) and increased HDL-c levels (P = 0.003). There were found significant results among women. Conclusion: The elderly male smokers presented lower values of WC, BMI and HDL-c, but smokers presented increased NOx concentration, which is a oxidative stress biomarker associated with cardiovascular diseases. Therefore, it is important to emphasize the importance in preventing and adhering to smoking cessation to avoid cardiovascular comorbidities. [ABSTRACT FROM AUTHOR]