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Pretreatment Hepatitis B Viral Load Predicts Long-Term Hepatitis B Response After Anti-Hepatitis C Therapy in Hepatitis B/C Dual-Infected Patients.
- Source :
-
Journal of Infectious Diseases . 4/15/2019, Vol. 219 Issue 8, p1224-1233. 10p. - Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>We aimed to investigate the long-term outcomes in hepatitis B (HBV)/hepatitis C virus (HCV) dual-infected patients after anti-HCV therapy.<bold>Methods: </bold>A total of 192 HBV/HCV dual-infected patients who had received pegylated interferon treatment were recruited. The investigation outcomes included HBV DNA ≥2000 IU/mL, with or without alanine aminotransferase (ALT) ≥2-fold the upper limit of normal, and hepatitis B surface antigen (HBsAg) seroclearance.<bold>Results: </bold>Four (2.1%) patients developed early HBV reactivation before the end of treatment. Fifty (26.6%) of the remaining patients had an episode of HBV DNA ≥2000 IU/mL in a mean follow-up of 68.8 months. The risk was 4.6 per 100 person years. Only 19 (10.1%) patients developed concomitant ALT flare with oral HBV antiviral therapy; the risk was 1.7 per 100 person years. Despite HBV flare, 67 (34.9%) patients had a favorable outcome of HBsAg seroclearance. The probability was 5.7 per 100 person years. A pretreatment HBV DNA level of 300 IU/mL served as an independent predictor for all the outcomes. The combined pretreatment HBV DNA level and HCV response further enhanced the prediction of HBV flare and HBsAg seroclearance.<bold>Conclusions: </bold>A pretreatment HBV DNA level of 300 IU/mL predicts HBV flare and HBsAg seroclearance after anti-HCV therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VIRAL hepatitis
*HEPATITIS B
*HEPATITIS associated antigen
*HEPATITIS C
*VIRAL load
*ANTIVIRAL agents
*COMPARATIVE studies
*HEPATITIS viruses
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*VIRAL antigens
*EVALUATION research
*ALANINE aminotransferase
*TREATMENT effectiveness
*PREDICTIVE tests
*MIXED infections
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 219
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 135845560
- Full Text :
- https://doi.org/10.1093/infdis/jiy648