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A MEMS-based measurement system for evaluating the force-length relationship of human induced pluripotent stem cell-derived cardiomyocytes adhered on a substrate.
- Source :
-
Journal of Micromechanics & Microengineering . May2019, Vol. 29 Issue 5, p1-1. 1p. - Publication Year :
- 2019
-
Abstract
- This paper reports on a method for evaluating the force-length relationship of adhering human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) on the substrate using a measurement system comprising of a micromachined movable plate and a piezoresistive force probe. The cells on the plate are stretched by pushing the movable plate with the piezoresistive cantilever, which is actuated by a piezo stage. The twitch forces and the applied stretch are measured quantitatively with the piezoresistive cantilever. The results demonstrated that the twitch forces of the hiPSC-CMs increased when a stretch was applied. This evaluation method improves the understanding of the intrinsic force-length relationship of hiPSC-CMs at the cellular scale. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLURIPOTENT stem cells
*EVALUATION methodology
*PLATE
*CANTILEVERS
*MEASUREMENT
Subjects
Details
- Language :
- English
- ISSN :
- 13616439
- Volume :
- 29
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Micromechanics & Microengineering
- Publication Type :
- Academic Journal
- Accession number :
- 135816596
- Full Text :
- https://doi.org/10.1088/1361-6439/ab093d