A study of lipid profile and ECG changes in chronic kidney disease patients.

Introduction: Hyperlipidemia, one of the important risk factor of atherosclerosis, is an abnormality commonly encountered in patients with chronic kidney disease. There are several other important risk factors, such as smoking, proteinuria, oxidative stress, inflammation and dyslipidemia that independently or in combination with elevated blood pressure, can cause deterioration in renal function. Aim of the study: To analyze lipid alterations that can occur in chronic kidney disease patients. Materials and methods: This study was conducted among 50 patients with chronic kidney disease. All the patients with established chronic kidney disease ensured with radiological evidence and on conservative treatment were included in the study. Lipid profile parameters are estimated under standard techniques. Results: Total cholesterol (TC), Triglycerides (TGL), High-Density Lipoprotein (HDL), and Low- Density Lipoprotein (LDL) of all the patients were investigated for the lipid profile study. It was found that the majority (80%) of the study participants were found to have low HDL, 62% of the participants were found to have a high triglyceride level. Overall, seven patients (14%) showed abnormal lipid profile with respect to all the four parameters. Conclusion: HDL-C levels were lower and triglycerides, total cholesterol, and TGL levels were higher in the study group. There is a statistically significant increase in serum triglycerides level in patients with CKD stage 3, 4 and 5. Predominant lipid abnormalities were reduced HDL-C levels and elevated TGL. [ABSTRACT FROM AUTHOR]