Abstract 16249: Increased All-Cause Mortality in Patients With Schizophrenia Following Acute Coronary Syndrome.

Background: Being diagnosed with schizophrenia is associated with an increased risk of developing cardiovascular diseases such as Acute Coronary Syndrome (ACS). The aim of this study is to investigate the effect of schizophrenia on all-cause mortality, reinfarction and stroke rates following ACS. The length of hospital stay following admission for ACS and prevalence of cardiac risk factors are also investigated. Methods: Data from three nationwide databases in Denmark were used in this study, including; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000-2014 were identified and categorized for an additional diagnosis of schizophrenia ICD-10 F20. The patients were matched 1:2 to a psychiatric healthy control (PHC) population on gender, age and year of first ACS diagnosis. The cardiac risk factors investigated were anemia, hypertension, diabetes mellitus (type 1 and 2) and hyperlipidemia. Results: A total of 1,383 patients diagnosed with any ACS were analyzed (schizophrenia = 461, PHC = 922). The mean age at the time of ACS diagnosis was 61.7 years and 69.0% were males. Having schizophrenia was associated with post-ACS all-cause mortality hazard ratios (HR) of 2.70 (CI 95%: 2.24-3.24) and post-ACS stroke HR of 1.77 (CI 95%: 1.11-2.82). No difference was found in the reinfarction rates between the populations. The length of hospital stays fluctuated from a lowest mean of 7.7 days (CI 95%: 5.4-10.0) to a highest mean of 9.7 days (CI 95%: 5.14-14.2). However, none of the comparisons on LoS resulted in statistically significant differences. Patients with schizophrenia were more likely to have anemia and there were no differences in prevalence of the remaining cardiac risk factors investigated. Conclusion: Patients with schizophrenia had increased all-cause mortality and stroke rates following ACS. However, no difference was found in the length of hospital stay between the populations. The only cardiac risk factor with a higher prevalence in the population with schizophrenia was anemia. [ABSTRACT FROM AUTHOR]