Abstract 15388: Demographic and Biological Factors Associated With Baseline and Serial Changes in Circulating NT-proBNP and High-Sensitivity Cardiac Troponin T in the Dallas Heart Study.

Introduction: N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known CVD. However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurements of NT-proBNP and hs-cTnT in a contemporary multi-ethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 3254 participants of Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD in each of its two phases (2000-2002 and 2007-2009). Variables collected included demographic and risk factors, body composition via DEXA and MRI, coronary artery calcium (CAC) by CT, and cardiac dimensions and function by cMRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.043), with only moderate correlation between change values (rho 0.179). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race (Table). NT-proBNP was more strongly associated with measures of body composition than hs-cTnT. At baseline, both NT-proBNP and hs-cTnT associated with LVEDV and wall thickness, but only NT-proBNP associated with LA size. Changes in cardiac dimensions between phases were associated with changes in NT-proBNP but not hs-cTnT (Table). Conclusions: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are non-redundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways. [ABSTRACT FROM AUTHOR]